abstract：:Seizure-induced cardiorespiratory autonomic dysfunction is a major cause of sudden unexpected death in epilepsy (SUDEP), and the underlying mechanism is unclear. Seizures lead to increased synthesis, and release of glutamate, pituitary adenylate cyclase activating polypeptide (PACAP), and other neurotransmitters, and ...

journal_title：Respiratory physiology & neurobiology

authors： Bhandare AM,Kapoor K,Farnham MM,Pilowsky PM

更新日期：2016-06-01 00:00:00

abstract：:The respiratory system is densely innervated by sensory neurons arising from the jugular (superior) and nodose (inferior) vagal ganglia. However, a distinction exists between jugular and nodose neurons as these ganglia developmentally originate from the neural crest and the epibranchial placodes, respectively. This di...

journal_title：Respiratory physiology & neurobiology

authors： Driessen AK,Farrell MJ,Mazzone SB,McGovern AE

更新日期：2016-06-01 00:00:00

abstract：:Intermittent hypoxia induces plasticity in neural networks controlling breathing and cardiovascular function. Studies demonstrate that mechanisms causing cardiorespiratory plasticity rely on intracellular signalling pathways that are activated by specific neurotransmitters. Peptides such as serotonin, PACAP and orexin...

journal_title：Respiratory physiology & neurobiology

authors： Kim SJ,Kim YJ,Kakall Z,Farnham MM,Pilowsky PM

更新日期：2016-06-01 00:00:00

abstract：:It has been more than thirty years since the in vitro brainstem-spinal cord preparation was first presented as a method to study automatic breathing behaviors in the neonatal rat. This straightforward preparation has led to an incredible burst of information about the location and coordination of several spontaneously...

journal_title：Respiratory physiology & neurobiology

authors： Vincen-Brown MA,Whitesitt KC,Quick FG,Pilarski JQ

更新日期：2016-04-01 00:00:00

abstract：:Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three resp...

journal_title：Respiratory physiology & neurobiology

authors： Perry SF,Tzaneva V

更新日期：2016-04-01 00:00:00

abstract：:Epidemiological studies have shown that children are more susceptible to adverse respiratory effects of passive smoking than adults. The goal of this study is to elucidate the possible neural mechanism induced by exposure to passive smoking during early life. Postnatal day (PD) 2 and PD 21 mice were exposed to side-st...

journal_title：Respiratory physiology & neurobiology

authors： Wu ZX,Hunter DD,Batchelor TP,Dey RD

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare pediatric disease of unknown cause. Here, in response to a recent case report describing a ROHHAD patient who suffered from secondary narcolepsy confirmed by an absence of hypocre...

journal_title：Respiratory physiology & neurobiology

authors： Barclay SF,Rand CM,Gray PA,Gibson WT,Wilson RJ,Berry-Kravis EM,Ize-Ludlow D,Bech-Hansen NT,Weese-Mayer DE

更新日期：2016-01-15 00:00:00

abstract：:A deficiency of surfactant proteins A and D has been proposed as a mechanism in airway remodeling, which is one characteristic of chronic obstructive pulmonary disease (COPD). We recently showed that in vitro nicotine exposure induces Wnt3a/β-catenin activation, which is a pathway that has also been implicated in alte...

journal_title：Respiratory physiology & neurobiology

authors： Zou W,Liu S,Hu J,Sheng Q,He F,Li B,Ran P

更新日期：2016-01-15 00:00:00

abstract：:Dyspnea on exertion (DOE) is a common symptom in obesity. We investigated whether aerobic exercise training without weight loss could reduce DOE. Twenty-two otherwise healthy obese women participated in a 12-week supervised aerobic exercise training program, exercising 30 min/day at 70-80% heart rate reserve, 4 days/w...

journal_title：Respiratory physiology & neurobiology

authors： Bernhardt V,Stickford JL,Bhammar DM,Babb TG

更新日期：2016-01-15 00:00:00

abstract：:Chronic exposure to sustained hyperoxia alters the development of the respiratory control system, but the respiratory effects of chronic intermittent hyperoxia have rarely been investigated. We exposed newborn rats to short, repeated bouts of 30% O2 or 60% O2 (5 bouts h(-1)) for 4-15 days and then assessed their hypox...

journal_title：Respiratory physiology & neurobiology

authors： Logan S,Tobin KE,Fallon SC,Deng KS,McDonough AB,Bavis RW

更新日期：2016-01-01 00:00:00

abstract：:Neonatal bronchopulmonary dysplasia (BPD) might lead to an increased risk for brain injury. The present study aims to investigate the effects of neonatal BPD on neuronal apoptosis in the hippocampus and cognitive function and to explore the underlying mechanisms. The results revealed that BPD model rat pups exhibited ...

journal_title：Respiratory physiology & neurobiology

authors： Yin R,Yuan L,Ping L,Hu L

更新日期：2016-01-01 00:00:00

abstract：:Apnea after exercise may evoke a neurally mediated conflict that may affect apneic time and create a cardiovascular strain. The physiological responses, induced by apnea with face immersion in cold water (10 °C), after a 3-min exercise bout, at 85% of VO2max,were examined in 10 swimmers. A pre-selected 40-s apnea, com...

journal_title：Respiratory physiology & neurobiology

authors： Konstantinidou S,Soultanakis H

更新日期：2016-01-01 00:00:00

abstract：:Although it has been recognized for more than a century, we still do not know how the two vagus nerves interact to produce Hering-Breuer reflex. In the current study, we tested the hypothesis that the vagus nerves interact via a multiplicative effect. We examined the Hering-Breuer reflex before and after unilateral (f...

journal_title：Respiratory physiology & neurobiology

authors： Song N,Liu J,Proctor M,Yu J

更新日期：2015-12-01 00:00:00

abstract：:This article constitutes a review of the studies performed by the group of the late A. Guz and other authors on the subjects of lung reflexes and perceptions of respiration. The experimental data suggest that the lung inflation and deflation reflexes are present in man, mediated by large myelinated afferent nerve fibr...

journal_title：Respiratory physiology & neurobiology

authors： Noble MI

更新日期：2015-10-01 00:00:00

abstract：:We developed and tested a semi-automated algorithm to generate large data sets of ventilatory information (amplitude, premotor drive and timing) across a range of motor behaviors. Adult spontaneously breathing, anesthetized mice (n = 27) underwent measurements of transdiaphragmatic pressure (Pdi) during eupnea, hypoxi...

journal_title：Respiratory physiology & neurobiology

authors： Medina-Martínez JS,Greising SM,Sieck GC,Mantilla CB

更新日期：2015-08-15 00:00:00

abstract：:We evaluated the role of vagal reflexes in a mouse model of allergen-induced airway hyperreactivity. Mice were actively sensitized to ovalbumin then exposed to the allergen via inhalation. Prior to ovalbumin inhalation, mice also received intratracheally-instilled particulate matter in order to boost the allergic resp...

journal_title：Respiratory physiology & neurobiology

authors： McAlexander MA,Gavett SH,Kollarik M,Undem BJ

更新日期：2015-07-01 00:00:00

abstract：:Sleep disordered breathing (SDB) with recurrent apnea is a major health problem affecting several million adult men and women. Humans with SDB are prone to develop hypertension. Studies on rodents established that exposure to chronic intermittent hypoxia (CIH) alone is sufficient to induce hypertension similar to that...

journal_title：Respiratory physiology & neurobiology

authors： Kumar GK,Nanduri J,Peng YJ,Prabhakar NR

更新日期：2015-04-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKI), erlotinib and gefitinib are small molecule inhibitors which are used for the treatment of lung cancer. But, the development of drug resistance has been reported as one of the major setbacks in oncology. This study focused on the mechanisms leading to secondary resistance by assessing ...

journal_title：Respiratory physiology & neurobiology

authors： Simasi J,Oelkrug C,Schubert A,Nieber K,Gillissen A

更新日期：2015-04-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes partic...

journal_title：Respiratory physiology & neurobiology

authors： Ciepiela O,Ostafin M,Demkow U

更新日期：2015-04-01 00:00:00

abstract：:Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (VC) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the men...

journal_title：Respiratory physiology & neurobiology

authors： Smith JR,Brown KR,Murphy JD,Harms CA

更新日期：2015-01-01 00:00:00

abstract：:Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c...

journal_title：Respiratory physiology & neurobiology

authors： Xie J,Xi Y,Zhang Q,Lai K,Zhong N

更新日期：2015-01-01 00:00:00

abstract：:The prefrontal cortex is one of the key areas of the central mechanism of cardiovascular and respiratory control. Disinhibition of the prelimbic medial prefrontal cortex elicits tachypnoeic responses in anesthetized rats (Hassan et al., J. Physiol. 591: 6069-6088, 2013). The current study examines the effects of inhib...

journal_title：Respiratory physiology & neurobiology

authors： Bondarenko E,Hodgson DM,Nalivaiko E

更新日期：2014-12-01 00:00:00

abstract：:Effect of time and phosphatidylcholines (PCs) on lubrication of damaged mesothelium has been investigated. Marked increase in coefficient of kinetic friction (μ) of pleural specimens after mesothelial blotting and rewetting decreased by 23.4±3.5%, 41.8±3.8%, and 40.5±2.7% after 30min, 1h, and 2h. Hence, damaged mesoth...

journal_title：Respiratory physiology & neurobiology

authors： Bodega F,Sironi C,Porta C,Agostoni E

更新日期：2014-11-01 00:00:00

abstract：:The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. Howe...

journal_title：Respiratory physiology & neurobiology

authors： Kidder IJ,Mudery JA,Bailey EF

更新日期：2014-10-01 00:00:00

abstract：:We previously showed that nasal pressure support ventilation (nPSV) can lead to active inspiratory laryngeal narrowing, which originates from the stimulation of bronchopulmonary receptors. Among the three major types of bronchopulmonary receptors, which are variably stimulated by lung distension, C-fiber endings are r...

journal_title：Respiratory physiology & neurobiology

authors： Samson N,Niane L,Nault S,Nadeau C,Praud JP

更新日期：2014-10-01 00:00:00

abstract：:Antioxidant therapy attenuates pulmonary hypertension (PH). In the present study, we tested the antioxidant effects of fasudil against PH in rats. Monocrotaline (MCT)-induced and chronic hypoxia-induced PH models of rats were established, and the haemodynamic and pathomorphologic results of three different doses of fa...

journal_title：Respiratory physiology & neurobiology

authors： Liu M,Wang Y,Zheng L,Zheng W,Dong K,Chen S,Zhang B,Li Z

更新日期：2014-09-15 00:00:00

abstract：:Reflux laryngitis in infants may be involved not only in laryngeal disorders, but also in disorders of cardiorespiratory control through its impact on laryngeal function. Our objective was to study the effect of reflux laryngitis on non-nutritive swallowing (NNS) and NNS-breathing coordination. Two groups of six newbo...

journal_title：Respiratory physiology & neurobiology

authors： Brisebois S,Samson N,Fortier PH,Doueik AA,Carreau AM,Praud JP

更新日期：2014-08-15 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR family, but the role of PPAR-β/δ in acute lung injury (ALI) induced by hyperbaric oxygen is unknown. In this study we investigated if PPAR-β/δ activation protects from hyperoxia-induced ALI in a rat model. ALI was ...

journal_title：Respiratory physiology & neurobiology

authors： Bao XC,Fang YQ,You P,Zhang S,Ma J

更新日期：2014-08-01 00:00:00

abstract：:Bronchoaspiration results in local deterioration of lung function through direct damage and/or indirect systemic effects related to neurohumoral pathways. We distinguished these effects by selectively intubating the two main bronchi in pigs while a PEEP of 4 or 10cm H2O was maintained. Gastric juice was instilled only...

journal_title：Respiratory physiology & neurobiology

authors： Fodor GH,Peták F,Erces D,Balogh AL,Babik B

更新日期：2014-08-01 00:00:00

abstract：:Newborn rats chronically exposed to moderate hyperoxia (60% O2) exhibit abnormal respiratory control, including decreased eupneic ventilation. To further characterize this plasticity and explore its proximate mechanisms, rats were exposed to either 21% O2 (Control) or 60% O2 (Hyperoxia) from birth until studied at 3-1...

journal_title：Respiratory physiology & neurobiology

authors： Bavis RW,van Heerden ES,Brackett DG,Harmeling LH,Johnson SM,Blegen HJ,Logan S,Nguyen GN,Fallon SC

更新日期：2014-07-01 00:00:00

abstract：:Bronchial responsiveness during methacholine (MCh) challenge was analysed in an elastase-induced mouse model of emphysema to explore the magnitude of the response in this model. Swiss mice were intratracheally instilled with saline or elastase (0.3 or 0.6 U). Twenty days afterward, mechanical ventilation data were col...

journal_title：Respiratory physiology & neurobiology

authors： Santos LM,de Brito Cervilha DA,Cabral LD,Garcia ÉK,Teixeira VP,Brito JM,Moriya HT,Soncini R

更新日期：2014-04-01 00:00:00

abstract：:Quality of life and prognosis of patients with myotonic dystrophy type 1 (MD1) often depend on the degree of lung function impairment. This study was designed to assess the respective prevalence of ventilatory restriction, hypoxaemia and hypercapnia in MD1 patients and to determine whether postural changes in lung fun...

journal_title：Respiratory physiology & neurobiology

authors： Poussel M,Kaminsky P,Renaud P,Laroppe J,Pruna L,Chenuel B

更新日期：2014-03-01 00:00:00

abstract：:Dietary inorganic nitrate supplementation causes physiological effects which may enhance exercise tolerance. However it is not known whether nitrate might alter cognitive function during exercise. In a double-blind, cross-over study, sixteen subjects ingested either nitrate-rich beetroot juice or a placebo and complet...

journal_title：Respiratory physiology & neurobiology

authors： Thompson KG,Turner L,Prichard J,Dodd F,Kennedy DO,Haskell C,Blackwell JR,Jones AM

更新日期：2014-03-01 00:00:00

abstract：:We investigated the influence of airway obstruction in the complexity of the airflow pattern in COPD and its use as a marker of disease activity. The sample entropy (SampEnV') and the variability (SDV') of the airflow pattern were measured in a group of 88 subjects with various levels of airway obstruction. Airway obs...

journal_title：Respiratory physiology & neurobiology

authors： Dames KK,Lopes AJ,de Melo PL

更新日期：2014-02-01 00:00:00

abstract：:Intermittent hypobaric hypoxia (IHH) exposure, accompanied or not with active recovery, can help to skeletal muscle repair. However, the erythropoietic response elicited can disturb blood rheology and thus alter the oxygen delivery to tissues. Male Sprague-Dawley rats were studied in two basal states: untrained and tr...

journal_title：Respiratory physiology & neurobiology

authors： Núñez-Espinosa C,Douziech A,Ríos-Kristjánsson JG,Rizo D,Torrella JR,Pagès T,Viscor G

更新日期：2014-02-01 00:00:00

abstract：:We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) ...

journal_title：Respiratory physiology & neurobiology

authors： Bartesaghi M,Beretta E,Pollastri L,Scotti V,Mandolesi G,Lanfranconi F,Miserocchi G

更新日期：2014-01-01 00:00:00

abstract：:In previous calculations of how the O2 transport system limits .VO2(max), it was reasonably assumed that mitochondrial P(O2) (Pm(O2)) could be neglected (set to zero). However, in reality, Pm(O2) must exceed zero and the red cell to mitochondrion diffusion gradient may therefore be reduced, impairing diffusive transpo...

journal_title：Respiratory physiology & neurobiology

authors： Cano I,Mickael M,Gomez-Cabrero D,Tegnér J,Roca J,Wagner PD

更新日期：2013-12-01 00:00:00

abstract：:Respiratory responses to bronchoconstriction in asthma have been partially assessed and their significance is unclear. In 44 mild asthma patients we investigated respiratory responses during increasing levels of methacholine-induced bronchoconstriction. Inspiratory muscle activity, tidal volume, inspiratory and expira...

journal_title：Respiratory physiology & neurobiology

authors： Lavorini F,Magni C,Chellini E,Camiciottoli G,Pistolesi M,Fontana GA

更新日期：2013-12-01 00:00:00

abstract：:Exposure to irritants such as tobacco smoke (TS) causes acute airway inflammation. Chronic exposure may cause airway remodeling contributing to enhanced airway resistance. We hypothesize that combining airway sensitization and inhalation of irritants enhances the number of mucous producing cells beyond either agent al...

journal_title：Respiratory physiology & neurobiology

authors： Pavuluri S,Hanus V,Bergren DR

更新日期：2013-12-01 00:00:00

abstract：:In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patient...

journal_title：Respiratory physiology & neurobiology

authors： Perry JC,Guindalini C,Bittencourt L,Garbuio S,Mazzotti DR,Tufik S

更新日期：2013-12-01 00:00:00